Chemosensitivity linked to p73 function
نویسندگان
چکیده
منابع مشابه
Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73.
Down-regulation of the Kpm/Lats2 tumor suppressor is observed in various malignancies and associated with poor prognosis in acute lymphoblastic leukemia. We documented that Kpm/Lats2 was markedly decreased in several leukemias that were highly resistant to conventional chemotherapy. Silencing of Kpm/Lats2 expression in leukemic cells did not change the rate of cell growth but rendered the cells...
متن کاملp73 expression and function in vestibular schwannoma.
OBJECTIVES To determine the expression of the p53 family member p73 in vestibular schwannoma (VS) and to determine the potential role of this tumor suppressor in regulating the proliferation of HEI193, a human papillomavirus E6-E7 immortalized VS cell line. METHODS Immunohistochemical staining was used to investigate the expression of p73 in 34 cases of archived VS tissue, while Western blot ...
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The development of multicellular organisms requires a balance between the cellular processes of proliferation, differentiation and death. These processes are important throughout the whole life of the organism. Daily, the DNA in our cells is under attack by agents that can cause damage. Thus, the cells have developed mechanisms to manage the DNA damage through activation of pathways leading to ...
متن کاملStructure and apoptotic function of p73
p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic act...
متن کاملThe p53 family protein p73 provides new insights into cancer chemosensitivity and targeting.
The p53 tumor suppressor is part of a small family of related proteins that includes two other members, p73 and p63. Interest in the p53 family members, their functions and their complex interactions and regulation, has steadily grown over recent years and does not show signs of waning. p73 is a major determinant of chemosensitivity in humans, and mutant p53 proteins carrying specific polymorph...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2003
ISSN: 1535-6108
DOI: 10.1016/s1535-6108(03)00078-3